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Boc Anhydride


Other Names:

Di-tert-butyl dicarbonate

Di-tert-butyl pyrocarbonate






General Information:


Structure:



CAS Number: 24424-99-5

Molecular Weight: 218.25 g/mol

Appearance: Colorless solid

Melting Point: 22-24 C

Boiling Point: 56-57 C


Boc anhydride has a melting point of only 22-24 C. It often starts to melt while being weighed out for a reaction. In order to use boc anhydride as a solid, it should be kept in a refrigerator and weighed out soon after being removed from the refrigerator.




Common Uses:


Reagent in the Boc protection of amines





Safety:


Boc anhydride causes eye and skin irritation and is harmful if inhaled. Boc anhydride is also a flammable solid. Care should be taken when running boc deprotections because it is a gas forming reaction.




References:


1) WO2014177977, page 65

2) Wikipedia: Di-tert-butyl dicarbonate (link)

3) www.sigmaaldrich.com: Di-tert-butyl dicarbonate (link)

4) www.alfa.com: A14708 Di-tert-butyl dicarbonate, 97+% (link)