New Jobs:

- Scientist (AbbVie)

- Process Chemist I (Waters)

- Mfg Assoc 2 (Illumina)

- Sr Scientist II (Alvogen)

Latest Internships:

- Cyclopure

  (Chemist)

- Sarepta

  (Nucleoside Chemistry)



BOP


Other Names:

(Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium

    hexafluorophosphate

Castro's reagent





General Information:


Structure:



CAS Number: 56602-33-6

Molecular Weight: 442.287 g/mol

Appearance: White crystalline powder


BOP is a reagent used occasionally in amide coupling reactions. The use of BOP forms Hexamethylphosphoramide (HMPA) as a by-pdt which is a known carcinogen. PyBOP is considered a safer alternative to BOP.




Common Uses:


Reagents for amide coupling reactions






Safety:


BOP forms Hexamethylphosphoramide (HMPA) as a by-pdt which is a known carcinogen.




References:


1) Patent Reference: WO2010038081, page 133, (33.8 MB)

2) Wikipedia: BOP reagent (link)

3) www.sigmaaldrich.com: (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (link)

4) www.alfa.com: A16140 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, 98% (link)