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BOP


Other Names:

(Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium

    hexafluorophosphate

Castro's reagent





General Information:


Structure:



CAS Number: 56602-33-6

Molecular Weight: 442.287 g/mol

Appearance: White crystalline powder


BOP is a reagent used occasionally in amide coupling reactions. The use of BOP forms Hexamethylphosphoramide (HMPA) as a by-pdt which is a known carcinogen. PyBOP is considered a safer alternative to BOP.




Common Uses:


Reagents for amide coupling reactions






Safety:


BOP forms Hexamethylphosphoramide (HMPA) as a by-pdt which is a known carcinogen.




References:


1) WO2010038081, page 133

2) Wikipedia: BOP reagent (link)

3) www.sigmaaldrich.com: (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (link)

4) www.alfa.com: A16140 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, 98% (link)