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XantPhos

4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene








General Information:


Structure:




CAS Number: 161265-03-8

Molecular Weight: 578.62 g/mol

Appearance: Colorless solid

Melting Point: 224-228 C


XantPhos is a bidentate bis-phosphine ligand with a wide bite angle. XantPhos is commonly used as a ligand in palladium catalyzed cross-coupling reactions such as Buchwald reactions.




Common Uses:


Ligand for Buchwald reactions



Procedure excerpt:

To a solution of the amine (2.81 g, 10 mmol) in dioxane (45 mL) was added the chloride (2.57 g, 9.55 mmol), XantPhos (231 mg, 0.40 mmol), and t-BuONa (1.44 g, 15 mmol). . . .

[full procedure]




References:


1) Patent Reference: WO2012129344, page 126, (7.3 MB)

2) Wikipedia: Xantphos (link)

3) www.sigmaaldrich.com: Xantphos (link)

4) www.alfa.com: H26241 4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene, 97% (link)