New Jobs:

- Research Inv II (BMS)

- Mgr - Chem Dev (Sage)

- Assoc Scientist (Mosaic)

- Sr Scientist (TPC Group)

Latest Internships:

- DAAD RISE - Germany

  (Summer Internship)

- ACS DOC SURF

  (Organic Chemistry)



SNAr (F)

[Aliphatic Amines (1o)]







Examples:


Example 1



A solution of the aryl fluoride (A) (7.6 g, 35 mmol), the amine (B) (6 g, 35 mmol), and DIEA (13.5 g, 105 mmol) in EtOH (70 mL) was refluxed for 14 h. The mixture was then cooled to 20 C and the resulting precipitate was filtered and washed with EtOH to provide the product as an orange powder. [11 g, 94%]


[Patent Reference: WO2015158653, page 36, (2.9 MB)]