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PMB Protection

Common Conditions (Protection):


p-methoxybenzyl protection is typically performed using p-methoxybenzyl chloride (PMBCl) in the presence of a base.[1][2]

Common Conditions (Deprotection):


Trifluoroacetic acid (TFA) is commonly employed to deprotect PMB ethers. Other acid sensitive functionalities may not be well tolerated.[1][2]


1) Kocienski, P. J.; Protecting Groups, 3rd Edition

2) Wuts, P. G. M.; Greene, T. W.; Greene's Protective Groups in Organic Synthesis, 4th Edition