Nitrile to Acid

(Acidic Conditions)

Examples:

Example 1

The SM (600 mg, 1.68 mmol) in 10N HCl (20 mL) was stirred at 100 C for 5 h. The reaction mixture was cooled to RT and 5N LiOH was added to pH 6. The resulting precipitate was filtered and dried to provide the product which was used without further purification.

[Patent Reference: WO2007089768, page 230, (20.6 MB)]