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Acid to Acid Chloride

(SOCl2)







Examples:


Example 1


Alcohol to Ketone rxn1


A mixture of the SM (1.0 g, 6.3 mmol) in ACN (20 mL) was treated with SOCl2 (0.8 mL). The resulting mixture was refluxed for 2 h. The solvent was removed in vacuo to provide the crude product as an oil which was used in the next step without further purification.


[Patent Reference: WO2010016005, page 89, (11.3 MB)]