New Jobs:

- Scientist (MilliporeSigma)

- Sr Chemist (Nanoly)

- Research Assoc (Gilead)

- Sr RS (Saimerak Pharma)

Latest Internships:

- Moderna

  (Discovery Chemistry)

- Merck

  (Chemistry)



TBS-Cl

tert-Butyldimethylsilyl Chloride


Other Names:

TBDMSCl

tert-Butyl(chloro)dimethylsilane

tert-Butyldimethylchlorosilane




General Information:


Structure:



CAS Number: 18162-48-6

Molecular Weight: 150.72 g/mol

Melting Point: 86-89 C

Boiling Point: 125 C


tert-Butyldimethylsilyl chloride (TBS-Cl) is generally used as a reagent for installing TBS protecting groups. A similar reagent is tert-butyldimethylsilyl trifluoromethanesulfonate (TBS-OTf).




Common Uses:


Reagent for TBS protection of alcohols



Procedure excerpt:

To a mixture of the SM (2.35 g, 5.36 mmol) and imidazole (729 mg, 10.72 mmol) in DMF (30 mL) at RT was added TBSCl (1.21 g, 8.04 mmol). The reaction mixture . . .

[full procedure]




References:


1) Patent Reference: WO2016011390, page 271, (20.2 MB)

2) www.sigmaaldrich.com: tert-Butyldimethylsilyl chloride (link)