Zinc Bromide

Other Names:

Zinc(II) bromide

Zinc dibromide

General Information:

Structure:

ZnBr₂

CAS Number: 7699-45-8

Molecular Weight: 225.20 g/mol

Appearance: White crystalline powder

Chemical Formula: ZnBr2

Melting Point: 394 C

Boiling Point: 697 C

Zinc bromide is a Lewis acid. Zinc bromide is sometimes used for the selective removal of Boc protecting groups from secondary amines.

Common Uses:

Reagent for Boc deprotection

Procedure excerpt:

To a solution the SM (0.34 g, 0.76 mmol) in DCM (10 mL) was added ZnBr2 (0.70 g, 3.1 mmol). The reaction mixture was stirred at RT for 3 days, after which time it was . . .

[full procedure]

References:

1) Patent Reference: WO2016014463, page 169, (6.7 MB)

2) Wikipedia: Zinc bromide (link)

3) www.sigmaaldrich.com: Zinc bromide (link)

4) Nigama, S. C. et al. Synthetic Communications, Vol. 19, Iss. 18, 1989, 3139-3142 (link)