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General Information:


CAS Number: 75-52-5

Molecular Weight: 61.04 g/mol

Appearance: Colorless liquid

Melting Point: -29 C

Boiling Point: 101.2 C

Density: 1.127 g/mL

Common Uses:

Reagent in Henry reactions

Procedure excerpt:

A mixture of the SM (150 g, 0.999 mol) and NH4OAc (30.8 g, 0.40 mol) in nitromethane (1.5 L) was refluxed for 16 h. The mixture was concentrated then diluted . . .

[full procedure]


Nitromethane is a flammable, toxic liquid.


1) Patent Reference: WO2016014463, page 94, (6.7 MB)

2) Wikipedia: Nitromethane (link)

3) Nitromethane (link)

4) Coates, R. M.; Denmark, S. E.; Handbook of Reagents for Organic Synthesis, Reagents, Auxiliaries, and Catalysts for C-C Bond Formation