NIS

(N-Iodosuccinimide)

General Information:

Structure:

CAS Number: 516-12-1

Molecular Weight: 224.98 g/mol

Appearance: White to slightly yellow/brown solid

Melting Point: 202-206 C

Common Uses:

Reagent in SEAr (Electrophilic Aromatic Substitution) iodinations

Procedure excerpt:

NIS (28.9 mmol) was added to a solution of the SM (5.00 g, 26.3 mmol) in AcOH (52.6 mL). The reaction mixture was stirred at RT for 90 min, after which time it was . . .

[full procedure]

References:

1) Patent Reference: WO2014201173, page 375, (19.7 MB)

2) Wikipedia: N-Iodosuccinimide (link)

3) www.sigmaaldrich.com: N-Iodosuccinimide (link)