New Jobs:

- Scientist (MilliporeSigma)

- Sr Chemist (Nanoly)

- Research Assoc (Gilead)

- Sr RS (Saimerak Pharma)

Latest Internships:

- Moderna

  (Discovery Chemistry)

- Merck

  (Chemistry)



HBTU


Other Names:

N,N,N',N'-Tetramethyl-O-(1H-benzotriazol-

    1-yl)uronium hexafluorophosphate

O-(Benzotriazol-1-yl)-N,N,N',N'-

    tetramethyluronium hexafluorophosphate




General Information:


Structure:



CAS Number: 94790-37-1

Molecular Weight: 379.25 g/mol

Appearance: White crystalline solid

Melting Point: 200 C




Common Uses:


Reagent for amide coupling reactions



Procedure excerpt:

To a solution of the acid (50 mg, 0.16 mmol), the amine (24 mg, 0.19 mmol), and DMF (1 mL) at 5 C was added HBTU (86 mg, 0.19 mmol) followed by DIEA (0.23 mL, 0.65 mmol). . . .

[full procedure]




References:


1) Patent Reference: WO2010032200, page 121, (6.2 MB)

2) Wikipedia: HBTU (link)

3) www.sigmaaldrich.com: HBTU (link)