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  (Nucleoside Chemistry)


(Diethylaminosulfur Trifluoride)

Other Names:

N,N-Diethylaminosulfur trifluoride

(Diethylamino)sulfur trifluoride


General Information:


CAS Number: 38078-09-0

Molecular Weight: 161.19 g/mol

Appearance: Colorless oil

Boiling Point: 30-32 C at 3 mmHg

Density: 1.22 g/mL

Diethylaminosulfur trifluoride (DAST) is a nucleophilic fluorinating agent with wide use in organic chemistry. Deoxo-Fluor is more thermally stable alternative to DAST.

Common Uses:

Fluorinating agent for converting alcohol to fluorides

Fluorinating agent for converting aldehydes to geminal difluorides

Fluorinating agent for converting ketones to geminal difluorides


1) Patent Reference: WO2016011930, page 160, (15.7 MB)

2) Patent Reference: WO2014201173, page 377, (19.7 MB)

3) Patent Reference: WO2016011930, page 152, (15.7 MB)

4) Wikipedia: Diethylaminosulfur trifluoride (link)

5) (Diethylamino)sulfur trifluoride (link)

6) Godhaviya, P. K.; Fluorinating Reagents: Properties, Preparation, Applications and Safety