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DAST

(Diethylaminosulfur Trifluoride)


Other Names:

N,N-Diethylaminosulfur trifluoride

(Diethylamino)sulfur trifluoride

Diethyl(trifluorosulfido)amine




General Information:


Structure:



CAS Number: 38078-09-0

Molecular Weight: 161.19 g/mol

Appearance: Colorless oil

Boiling Point: 30-32 C at 3 mmHg

Density: 1.22 g/mL


Diethylaminosulfur trifluoride (DAST) is a nucleophilic fluorinating agent with wide use in organic chemistry. Deoxo-Fluor is more thermally stable alternative to DAST.




Common Uses:


Fluorinating agent for converting alcohol to fluorides





Fluorinating agent for converting aldehydes to geminal difluorides





Fluorinating agent for converting ketones to geminal difluorides





References:


1) WO2016011930, page 160

2) WO2014201173, page 377

3) WO2016011930, page 152

4) Wikipedia: Diethylaminosulfur trifluoride (link)

5) www.sigmaaldrich.com: (Diethylamino)sulfur trifluoride (link)

6) Godhaviya, P. K.; Fluorinating Reagents: Properties, Preparation, Applications and Safety