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Aluminum Chloride


Other Names:

Aluminium chloride

Aluminium(III) chloride






General Information:


Structure:


AlCl3

CAS Number: 7446-70-0 (anhydrous)

Molecular Weight: 133.34 g/mol (anhydrous)

Appearance: Colorless to yellow solid

Chemical Formula: AlCl3

Melting Point: 190 C (anhydrous)


Aluminum chloride (AlCl3) is used as a Lewis acid catalyst for a variety of reactions. The most well-known application of AlCl3 is in Friedel-Crafts reactions. Friedel-Crafts alkylations generally only require a catalytic amount of AlCl3, whereas Friedel-Crafts acylations require greater than one equivalent of AlCl3. This is because the Lewis acidity of AlCl3 results in strong complexes with carbonyl groups (the acylating agent).




Common Uses:


Reagent for Friedel-Crafts alkylations





Reagent for Friedel-Crafts acylations





Safety:


Aluminum chloride reacts violently with H2O. Aluminum chloride fumes in air and should therefore be stored in a tightly sealed container and protected from moisture.




References:


1) WO2015089337, page 207

2) Wikipedia: Aluminium chloride (link)

3) www.sigmaaldrich.com: Aluminum chloride (link)

4) www.alfa.com: 12298 Aluminum chloride, anhydrous, Reagent Grade (link)

5) Reich, H. J.; Rigby, J. H.; Handbook of Reagents for Organic Synthesis, Acidic and Basic Reagents

6) Kurti, L.; Czako, B.; Strategic Applications of Named Reactions in Organic Synthesis