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  (Nucleoside Chemistry)

Acetyl Chloride

Other Names:

Ethanoyl chloride

Acyl chloride

General Information:


CAS Number: 75-36-5

Molecular Weight: 78.49 g/mol

Appearance: Colorless liquid

Chemical Formula: CH3COCl

Melting Point: -112 C

Boiling Point: 52 C

Density: 1.104 g/mL at 25 C

Acetyl chloride is a simple acyl halide commonly used to introduce acetyl groups onto amine or alcohol functionalities of substrates. Acetyl groups are sometimes used as protecting groups for amines. A common alternative to acetyl chloride for acetylation reactions is acetic anhydride.

Common Uses:

Reagent for the acetyl protection of amines

Reagent for the acetylation of alcohols

Reagent in Friedel-Crafts acylations


Acetyl chloride is a corrosive, volatile liquid.


1) Patent Reference: WO2016011390, page 63, (20.2 MB)

2) Wikipedia: Acetyl chloride (link)

3) Acetyl chloride (link)

4) 43262 Acetyl chloride, 99+% (link)

5) Kurti, L.; Czako, B.; Strategic Applications of Named Reactions in Organic Synthesis