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Acetyl Chloride


Other Names:

Ethanoyl chloride

Acyl chloride






General Information:


Structure:



CAS Number: 75-36-5

Molecular Weight: 78.49 g/mol

Appearance: Colorless liquid

Chemical Formula: CH3COCl

Melting Point: -112 C

Boiling Point: 52 C

Density: 1.104 g/mL at 25 C


Acetyl chloride is a simple acyl halide commonly used to introduce acetyl groups onto amine or alcohol functionalities of substrates. Acetyl groups are sometimes used as protecting groups for amines. A common alternative to acetyl chloride for acetylation reactions is acetic anhydride.




Common Uses:


Reagent for the acetyl protection of amines





Reagent for the acetylation of alcohols





Reagent in Friedel-Crafts acylations





Safety:


Acetyl chloride is a corrosive, volatile liquid.




References:


1) WO2016011390, page 63

2) Wikipedia: Acetyl chloride (link)

3) www.sigmaaldrich.com: Acetyl chloride (link)

4) www.alfa.com: 43262 Acetyl chloride, 99+% (link)

5) Kurti, L.; Czako, B.; Strategic Applications of Named Reactions in Organic Synthesis