New Jobs:

- Scientist (AbbVie)

- Process Chemist I (Waters)

- Mfg Assoc 2 (Illumina)

- Sr Scientist II (Alvogen)

Latest Internships:

- Cyclopure

  (Chemist)

- Sarepta

  (Nucleoside Chemistry)



DBU

(1,8-Diazabicyclo[5.4.0]undec-7-ene)


Other Names:

2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine






General Information:


Structure:



CAS Number: 6674-22-2

Molecular Weight: 152.24 g/mol

Appearance: Colorless to light yellow liquid

Density: 1.018 g/mL at 25 C


DBU is considered to be a non-nucleophilic base. DBU can serve as a base, catalyst, or complexing ligand in a wide variety of reactions.




Common Uses:


Reagent for conversion of alcohols to azides (DPPA + DBU)





Catalyst in some Michael addition reactions





References:


1) Patent Reference: WO2015144799, page 343, (18.8 MB)

2) Patent Reference: WO2014110000, page 30, (2.6 MB)

3) Wikipedia: 1,8-Diazabicyclo[5.4.0]undec-7-ene (link)

4) www.sigmaaldrich.com: 1,8-Diazabicyclo[5.4.0]undec-7-ene (link)

5) Reich, H. J.; Rigby, J. H.; Handbook of Reagents for Organic Synthesis, Acidic and Basic Reagents