Dppf

[1,1'-Bis(diphenylphosphino)ferrocene]

Other Names:

1,1'- Bis(diphenylphosphanyl) ferrocene

1,1'- Ferrocenediyl- bis(diphenylphosphine)

General Information:

Structure:

CAS Number: 12150-46-8

Molecular Weight: 554.38 g/mol

Melting Point: 181-183 C

1,1'-Bis(diphenylphosphino)ferrocene (Dppf) is a diphosphine ligand used in homogeneous catalysis. Dppf is commonly used in palladium-catalyzed coupling reactions, but also is used with a variety of other Group 9 and 10 transition metals such as rhodium and nickel.

Common Uses:

Ligand in palladium catalyzed reactions (ex. cyanation)

Procedure excerpt:

To a solution of the SM (16.53 g, 72 mmol) in DMF (20 mL) was added dppf (8 g, 14.43 mmol) and ZnCN2 (5.08 g, 43.3 mmol), followed by Pd2(dba)3 (6.61 g, 7.22 mmol). . . .

[full procedure]

References:

1) Patent Reference: WO2010032200, page 132, (6.2 MB)

2) Wikipedia: 1,1'-Bis(diphenylphosphino)ferrocene (link)

3) www.sigmaaldrich.com: DPPF (link)

4) www.alfa.com: B21166 1,1’-Bis(diphenylphosphino)ferrocene, 97% (link)

5) Molander, G. A.; Handbook of Reagents for Organic Synthesis, Catalyst Components for Coupling Reactions