New Jobs:

- Sr Scientist (Epizyme)

- Scientist (Agios)

- Postdoc (Mount Sinai)

- Sr Scientist (Merck)

Latest Internships:

- Lubrizol

  (Summer 2018)

- Ionis

  (Summer 2018)



Urea Formation

(Triphosgene)







Examples:


Example 1



To a solution of triphosgene (26.4 mg, 0.090 mmol) in ACN (1 mL) at -5 C was added a solution of B (91.6 mg, 0.26 mmol) and TEA (73.2 uL) in ACN (1 mL) over 5 min. Then was added a solution of A (125 mg, 0.090 mmol) and TEA (73.2 uL) in ACN (1 mL). The reaction mixture was slowly warmed to RT and stir for 3 h. The mixture was concentrated and the resulting material was purified by RP-HPLC to provide the product as a flaky shiny white solid. [132 mg, 75%] [WO2002016360, page 18]




Related Books: