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Urea Formation



Example 1

To a solution of the amine (A) (100 mg, 0.27 mmol) in DMF (1 mL) was added a solution of the isocyanate (B) (75 mg, 0.45 mmol) in DMF (1 mL). The reaction mixture was stirred at RT overnight. The mixture was concentrated in vacuo and the resulting material was purified by RP-HPLC to provide the product as a white solid. [100 mg, 73%]

[Patent Reference: WO2002016360, page 18, (1.3 MB)]