New Jobs:

- Sr Scientist (Epizyme)

- Scientist (Agios)

- Postdoc (Mount Sinai)

- Sr Scientist (Merck)

Latest Internships:

- Lubrizol

  (Summer 2018)

- Ionis

  (Summer 2018)



Urea Formation

(isocyanates)







Examples:


Example 1



To a solution of the amine (100 mg, 0.27 mmol) in DMF (1 mL) was added a solution of the isocyanate (75 mg, 0.45 mmol) in DMF (1 mL). The reaction mixture was stirred at RT overnight. The mixture was concentrated in vacuo and the resulting material was purified by RP-HPLC to provide the product as a white solid. [100 mg, 73%] [WO2002016360, page 18]