New Jobs:

- Scientist (Bio-Rad)

- Scientist (Janssen)

- Research Scientist (UES)

- Med Chemist (FCCDC)

Latest Internships:

- Vertex

  (Summer 2019)

- Janssen

  (Discovery Chem)



THP Deprotection

(Pyridinium p-TsOH)







Examples:


Example 1



To a stirred solution of the SM (19.0 g, 57.6 mmol) in MeOH (150 mL) was added pyridinium p-TsOH (1.46 g, 5.80 mmol). The reaction mixture was stirred at 50 C for 19 h (monitored by TLC). The mixture was concentrated in vacuo and the resulting material was purified on silica gel (0-15% EtOAc/hexane) to provide the product as a white solid. [90%]


[Patent Reference: WO2010045258, page 121, (12.0 MB)]