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Substitution (Mesylate)



Example 1

To a solution of the SM (0.3 g, 0.97 mmol) in DMF (10 mL) was added NaN3 (127 mg, 1.94 mmol) at 0 C. The reaction mixture was stirred at RT for 16 h. The mixture was diluted with EtOAc and H2O.  The org layer was separated, dried (Na2SO4), and concentrated to provide the crude product as a syrup which was used in the next step without further purification. [170 mg]

[Patent Reference: WO2014149164, page 398, (23.7 MB)]