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Nitrile to Amine

(LiAlH4)







Examples:


Example 1



To a solution of the SM (0.792 g, 2.88 mmol) in dry ether under argon at 0 C was added LiAlD4 (0.225 g, 5.35 mmol). The reaction was stirred for 1 h, after which time was slowly added sat aq Na2SO4. The mixture was stirred until a precipitate formed, then anhydrous MgSO4 was added. The mixture was filtered and purified by flash chromatography (10-50% EtOAc/hexane) to provide the product as a colorless oil. [0.226 g, 28%] [UK Pat App GB2463151A, page 153]