New Jobs:
- Synthetic Chemist (Corteva)
- Scientist (Firmenich)
- Sr Scientist (Amgen)
- Head of Med Chem (Maze)
Please take a moment to tell us how we can improve the website (email)
- Home
- Chlorination
Chlorination
Common Conditions:
NCS
Sufficiently activated aromatic rings (ex. anilines and phenols) are readily chlorinated with N-chlorosuccinimide (NCS). Chlorination of a less reactive ring system may need to be catalyzed (ex. acid catalyzed chlorination).[1][2]
References:
1) Carey, F. A.; Sundberg, R. J.; Advanced Organic Chemistry, Part B: Reactions and Synthesis, 5th Edition
2) Caron, S.; Practical Synthetic Organic Chemistry