New Jobs:

- Scientist (AbbVie)

- Process Chemist I (Waters)

- Mfg Assoc 2 (Illumina)

- Sr Scientist II (Alvogen)

Latest Internships:

- Cyclopure

  (Chemist)

- Sarepta

  (Nucleoside Chemistry)



t-Butyllithium


Other Names:

tert-Butyllithium

t-BuLi

tert-BuLi

Lithium-2-methyl-2-propanide




General Information:


Structure:




CAS Number: 594-19-4

Molecular Weight: 64.06 g/mol


t-Butyllithium (t-BuLi) is a strong base that can deprotonate weak carbon acids, especially when weaker organolithium bases such as n-BuLi and s-BuLi don't work well. t-BuLi is a pyrophoric reagent that easily catches fire when exposed to the moisture in air. A fatal accident involving t-BuLi occurred at UCLA, in 2008.




Safety:


t-BuLi is a pyrophoric reagent that may ignite spontaneously when exposed to air. Handling of t-BuLi should be done behind a shield. If a fire occurs, an appropriate Class D fire extinguisher should be used. t-BuLi fires can cause serious injury or death, as seen in the fatal accident involving t-BuLi that occurred at UCLA, in 2008.




References:


1) Wikipedia: tert-Butyllithium (link)

2) www.sigmaaldrich.com: tert-Butyllithium (link)

3) Reich, H. J.; Rigby, J. H.; Handbook of Reagents for Organic Synthesis, Acidic and Basic Reagents