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Ethyl Acetate

Other Names:

Ethyl ethanoate

General Information:


CAS Number: 141-78-6

Molecular Weight: 88.11 g/mol

Appearance: Colorless liquid

Melting Point: -83 C

Boiling Point: 77 C

Density: 0.90 g/mL at 20 C

Ethyl acetate (EtOAc) is a common solvent for extractions and purifications. EtOAc is a common solvent for certain reactions such as catalytic reductions involving palladium on carbon (Pd/C). However, EtOAc does not see widespread use as a solvent for reactions due to its tendency to hydrolyze under acidic or basic conditions.

Common Uses:

Solvent for reactions

Solvent for silica gel chromatography

Procedure excerpt:

…The resulting material was purified by silica gel column chromatography (10% EtOAc/hexane) to provide the product…

Solvent for extractions

Procedure excerpt:

…The mixture was concentrated in vacuo, diluted with H2O (200 mL), and extracted with EtOAc (2 x 200 mL). The combined organics…

Solvent for trituration

Procedure excerpt:

…The solid was slurried in EtOAc (350 mL) for 45 min at 15 C. The mixture was filtered, rinsing with 15 C EtOAc (2 x 250 mL), and dried…


Ethyl acetate (EtOAc) is a very flammable liquid. EtOAc has a relatively low toxicity.


1) Patent Reference: WO2002016361, page 35, (2.1 MB)

2) Patent Reference: WO2015129926, page 79, (21.5 MB)

3) Patent Reference: WO2015051043, page 98, (9.7 MB)

4) Patent Reference: WO2014110000, page 19, (2.6 MB)

5) Wikipedia: Ethyl acetate (link)

6) Ethyl acetate (link)