New Jobs:

- Assoc RS (Exelixis)

- Org/Med Chemist (Flavine)

- Process Chemist (Avista)

- Sr Chemist (Laxmi)

Latest Internships:

- Theravance

  (Medicinal Chemistry)

- Cepheid

  (Chemistry)



Ethyl Acetate


Other Names:

Ethyl ethanoate







General Information:


Structure:



CAS Number: 141-78-6

Molecular Weight: 88.11 g/mol

Appearance: Colorless liquid

Melting Point: -83 C

Boiling Point: 77 C

Density: 0.90 g/mL at 20 C


Ethyl acetate (EtOAc) is a common solvent for extractions and purifications. EtOAc is a common solvent for certain reactions such as catalytic reductions involving palladium on carbon (Pd/C). However, EtOAc does not see widespread use as a solvent for reactions due to its tendency to hydrolyze under acidic or basic conditions.




Common Uses:


Solvent for reactions





Solvent for silica gel chromatography



Procedure excerpt:

…The resulting material was purified by silica gel column chromatography (10% EtOAc/hexane) to provide the product…




Solvent for extractions



Procedure excerpt:

…The mixture was concentrated in vacuo, diluted with H2O (200 mL), and extracted with EtOAc (2 x 200 mL). The combined organics…




Solvent for trituration



Procedure excerpt:

…The solid was slurried in EtOAc (350 mL) for 45 min at 15 C. The mixture was filtered, rinsing with 15 C EtOAc (2 x 250 mL), and dried…




Safety:


Ethyl acetate (EtOAc) is a very flammable liquid. EtOAc has a relatively low toxicity.




References:


1) Patent Reference: WO2002016361, page 35, (2.1 MB)

2) Patent Reference: WO2015129926, page 79, (21.5 MB)

3) Patent Reference: WO2015051043, page 98, (9.7 MB)

4) Patent Reference: WO2014110000, page 19, (2.6 MB)

5) Wikipedia: Ethyl acetate (link)

6) www.sigmaaldrich.com: Ethyl acetate (link)