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  (Nucleoside Chemistry)


(Boron Trifluoride Diethyl Etherate)

Other Names:

Boron trifluoride ethyl etherate

General Information:


CAS Number: 109-63-7

Molecular Weight: 141.93 g/mol

Appearance: Light yellow liquid

Melting Point: -58 C

Boiling Point: 126-129 C

Density: 1.15 g/mL

Boron trifluoride diethyl etherate (BF3-OEt2) is a convenient, easy to handle source of boron trifluoride (BF3). BF3-OEt2 is a liquid, whereas BF3 is a gas.

Common Uses:

Reagent for SEM deprotection


Keep BF3-OEt2 away from moisture and oxidizing agents.


1) Patent Reference: WO2012149280, page 63, (4.1 MB)

2) Boron trifluoride diethyl etherate (link)

3) Reich, H. J.; Rigby, J. H.; Handbook of Reagents for Organic Synthesis, Acidic and Basic Reagents