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  (Process Chem)


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SEM Deprotection



Example 1

To a stirred solution of the SM (250 mg, 0.43 mmol) in THF (4 mL) was added TBAF (4 mL, 1M in THF). The reaction mixture was stirred at 80 C for 12 h. After cooling to RT, the mixture was diluted with EtOAc (20 mL), washed with H2O, and concentrated in vacuo. The crude material was purified by Prep HPLC (formic acid) to provide the product as a white solid. [24 mg, 12%]

[Patent Reference: WO2015140133, page 103, (11.7 MB)]