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General Information:


CAS Number: 302-01-2

Molecular Weight: 32.04 g/mol

Appearance: Colorless liquid

Melting Point: 1.4 C

Boiling Point: 113.5 C

Density: 1.021 g/mL

Basicity (pKb): 5.90

Hydrazine is a highly toxic liquid with numerous applications in organic chemistry. It has a pungent ammonia-like odor and is highly flammable. It can be purchased in anhydrous form or as the hydrate. Hydrazine is classified as a strong reducing agent and will react readily and exothermically with most oxidizing agents and mineral acids.

Common Uses:

Reagent in Wolff-Kishner reactions

Reagent for the deprotection of pthalimides


Hydrazine is highly toxic and is considered to be dangerously unstable in anhydrous form. Hydrazine is a flammable liquid. Mixtures of hydrazine vapor in the air are flammable between 4.7% and 100% hydrazine by volume. Water solutions of hydrazines cannot be ignited when the hydrazine concentration is below 40%.


1) US20080293730, page 8

2) Wikipedia: Hydrazine (link)

3) Hydrazine (link)

4) Reich, H. J.; Rigby, J. H.; Handbook of Reagents for Organic Synthesis, Acidic and Basic Reagents

5) 22nd Department of Defense Explosives Safety Seminar (link)