New Jobs:

- Scientist (MilliporeSigma)

- Sr Chemist (Nanoly)

- Research Assoc (Gilead)

- Sr RS (Saimerak Pharma)

Latest Internships:

- Moderna

  (Discovery Chemistry)

- Merck



Benzyl N-Succinimidyl Carbonate

Other Names:



General Information:


CAS Number: 13139-17-8

Molecular Weight: 249.22 g/mol

Appearance: White solid

Melting Point: 80-82 C

Benzyl N-succinimidyl carbonate (Cbz-OSu) is usually used for the Cbz protection of amines. A similar reagent is benzyl chloroformate.

Common Uses:

Reagent for the Cbz protection of amines

Procedure excerpt:

To a solution of the SM (30.5 g, 148.6 mmol) in THF/H2O (1:1, 400 mL) was added NaHCO3 (24.7 g, 294 mmol), followed by benzyl N-succinimidyl carbonate (44.0 g, 176 mmol) . . .

[full procedure]


1) Patent Reference: WO2011123693, page 70, (11.9 MB)

2) N-(Benzyloxycarbonyloxy)succinimide (link)

3) A12153 N-(Benzyloxycarbonyloxy)succinimide, 98% (link)

4) N-(N-Benzyloxycarbonyloxy)succinimide (link)