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CF₃ Acetyl Protection

(Ethyl Trifluoroacetate)

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Examples:

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Example 1

A solution of the SM (0.411 g, 1.47 mmol) and ethyl trifluoroacetate (0.5 mL, 4.19 mmol) in dry THF was stirred at RT for 15 min. The mixture was concentrated in vacuo to provide the product as a colorless oil, which was used in the next step without further purification. [0.545 g, 99%] [UK Pat App GB2463151A, page 124]