O-Demethylation

(NaSMe)

Examples:

Example 1

A mixture of the SM (3 g, 9.7 mmol) and aq NaSMe (18 mL, 38.9 mmol, 21% w/v) in DMF (75 mL) was heated to 60 C for 2 h, after which time it was cooled to RT, poured into H2O (150 mL), and acidified with 1.5N HCl. The resulting solids were filtered to provide the product as an off-white solid. [2.5 g]

[Patent Reference: WO2010038081, page 122, (33.8 MB)]