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- Amine to Amide (Coupling)
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- Mech (HATU)
Amine to Amide
(HATU)
Mechanism:
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Steps:
- The base deprotonates the carboxylic acid. The resulting carboxylate anion attacks the electron deficient carbon atom of HATU.
- The resulting HOAt anion reacts with the newly formed activated carboxylic acid derived intermediate to form an OAt activated ester.
- The amine reacts with the OAt activated ester to form the amide pdt.