Sodium Hydroxide

Other Names:

Caustic soda

Lye

General Information:

Structure:

CAS Number: 1310-73-2

Molecular Weight: 40.00 g/mol

Appearance: White solid

Chemical Formula: NaOH

Common Uses:

Base/reagent for the hydrolysis of esters to carboxylic acids

Procedure excerpt:

To a solution of the SM (270 mg, 1.04 mmol) in 1:1 THF/MeOH (10 mL) was added dropwise 1N NaOH (3 mL). The reaction mixture was stirred at 70 C for 2 h. . . .

[full procedure]

Base/reagent for the hydrolysis of nitriles to amides

Procedure excerpt:

A mixture of the SM (65 mg, 0.21 mmol) and NaOH (17 mg, 0.42 mmol) in 1:1 EtOH/H2O (2 mL) was stirred at 50 C for 4 h. After cooling to RT, the mixture was . . .

[full procedure]

Base/reagent for the hydrolysis of nitriles to carboxylic acids

Base/reagent for acetyl deprotections

Base/reagent for Cbz deprotections

Base in aldol condensations

Safety:

Sodium hydroxide is a strong base.

References:

1) Patent Reference: WO2014149164, page 301, (23.7 MB)

2) Patent Reference: WO2016011390, page 79, (20.2 MB)

3) Wikipedia: Sodium hydroxide (link)

4) www.sigmaaldrich.com: Sodium hydroxide (link)