HBTU

Other Names:

N,N,N',N'-Tetramethyl-O-(1H-benzotriazol-

1-yl)uronium hexafluorophosphate

O-(Benzotriazol-1-yl)-N,N,N',N'-

tetramethyluronium hexafluorophosphate

General Information:

Structure:

CAS Number: 94790-37-1

Molecular Weight: 379.25 g/mol

Appearance: White crystalline solid

Melting Point: 200 C

Common Uses:

Reagent for amide coupling reactions

Procedure excerpt:

To a solution of the acid (50 mg, 0.16 mmol), the amine (24 mg, 0.19 mmol), and DMF (1 mL) at 5 C was added HBTU (86 mg, 0.19 mmol) followed by DIEA (0.23 mL, 0.65 mmol). . . .

[full procedure]

References:

1) Patent Reference: WO2010032200, page 121, (6.2 MB)

2) Wikipedia: HBTU (link )

3) www.sigmaaldrich.com: HBTU (link )