[Bis(2-methoxyethyl)aminosulfur Trifluoride]
Structure:
CAS Number: 202289-38-1
Molecular Weight: 221.24 g/mol
Appearance: Clear yellow liquid
Density: 1.2 g/mL
Deoxo-Fluor is a nucleophilic fluorinating agent with wide use in organic chemistry. Deoxo-Fluor is more thermally stable than Diethylaminosulfur Trifluoride (DAST).
Reagent for the conversion of alcohols to fluorides
Procedure excerpt:
The SM (50 mg, 0.135 mmol) was dissolved in anhydrous DCM (2 mL), and the mixture was cooled to 0 C. Deoxo-Fluor (0.074 mL, 0.404 mmol) was added . . .
Reagent for the conversion of ketones to difluorides
Procedure excerpt:
In a plastic reaction vessel, the SM (0.57 g, 2.0 mmol) was dissolved in DCM (1 mL). To this solution was added Deoxo-Fluor (0.75 g, 3.4 mmol) followed by EtOH . . .
1) Patent Reference: WO2016010950, page 209, (18.8 MB)
2) Patent Reference: WO2016011390, page 399, (20.2 MB)
3) www.sigmaaldrich.com: Deoxo-Fluor (link)
4) www.tcichemicals.com: Bis(2-methoxyethyl)aminosulfur Trifluoride (link)
5) Godhaviya, P. K.; Fluorinating Reagents: Properties, Preparation, Applications and Safety