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SEM Deprotection

(HCl)





Examples


Example 1



A mixture of the SM (0.11 g, 0.33 mmol), EtOH (0.5 mL), and conc HCl (0.5 mL) was heated at about 80 C O/N. The mixture was concentrated to dryness and to the resulting residue was added sat aq NaHCO3. The mixture was extracted with 25% IPA/Chloroform. The org layer was washed with brine and concentrated in vacuo to provide the product as a yellow solid. [0.060 g, 87%] [WO2012149280, page 77]